Drug-induced Skin Reactions
نویسندگان
چکیده
Objective Recently, skin reactions to luteinizing hormone-releasing hormone (LH-RH) agonist therapy were reported after the 3-month depot type was released. We evaluate skin reactions to the 3-month depot type of LHRH agonist by questionnaires obtained from patients with prostate cancer who had been given a subcutaneous injection of LH-RH agonist. Materials and Methods A questionnaire regarding skin reactions to the subcutaneous injection of LH-RH agonist was given to 64 outpatients with prostate cancer from 6th October 2004 to 31st March 2005, including 31 with goserelin acetate (Zoladex® LA 10.8 mg depot: Group ZLA) and 33 leupropreline acetate 11.25 mg (Leuplin® SR 11.25 mg depot: Group LSR), and the results were analyzed. The content of the questionnaire was as follows: with or without skin reactions; pain, nodule, subcutaneous bleeding and other reactions; anxiety or not; how long the reactions continued. Results Five in Group ZLA (16.1%) and 8 in Group LSR (24.2%) had skin reactions. In Group ZLA, one patient had nodule, two patients complained of pain, and subcutaneous bleeding occurred in two patients. The nodule resolved in a week. In Group LSR, six patients had nodule and two patients complained of pain, but there were no patients with subcutaneous bleeding. Four of six nodules disappeared in a week, but other patients had nodule
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